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Home | Thomas Dalton PhD | Philosopher
M emories of my early childhood are clouded with uncertainties because I was essentially separated from my parents since the early age of seven.
I was born in Shanghai, China on April 6, My father had come there from Vienna, Austria after earning doctorates in law and business. My mother, born Renée Tapernoux, had arrived from France with her parents via Hanoi. When the case against Dreyfus collapsed in the early s my grandfather left for French Indochina, then called le Tonkin.
At age 7, my parents sent my two older brothers and me to La Châtaigneraie, phd thesis autobiography, a large Swiss boarding school overlooking Lake Geneva, phd thesis autobiography. My oldest brother, Raoul, was the first to leave to attend the ETH, the Swiss Federal Polytechnical Institute in Zürich where he was awarded a degree in engineering.
My brother Georges went to Oxford and read law. While in school, I formed a lifelong friendship phd thesis autobiography my classmate Wilfried Haudenschild who dazzled me with his tinkering abilities, off-the-wall ideas and mechanical inventiveness. Together we decided that one of us should go into the Sciences and the other into Medicine so that we could cure all the ills of the world. Another important event marked my High School days: I was admitted to the Geneva Conservatory of Music.
I decided on the spot that I wanted to study with him. Polonaise, he took me on, and that spelled the beginning of many enthralling years. Music had always played an important part in my life, to such an extent that I even wondered whether I should not make a career of it.
But finally I thought it better to keep music purely for pleasure. It was my goal to become a microbiologist but Fernand Chodat, the Professeur of Bacteriology, argued that there was little future in that field, phd thesis autobiography, which was probably the case in Switzerland at that time.
He advised me to get a diploma in Chemistry saying that, in any case, test tubes were of more use than a microscope to modern microbiologists. I therefore entered the School of Chemistry just at the start of World War II. Two years of quantitative inorganic analyses seemed endless.
Organic chemistry finally arrived like a breath of fresh air, if not a reprieve on life. For my thesis, I elected to work with Prof. Kurt H. Meyer, Head of the Department of Organic Chemistry. His main interest lay in the structure of polysaccharides, particularly starch and glycogen, phd thesis autobiography. To unravel the structure of these molecules, enzymes were needed: alpha- and beta-amylases, phosphorylase, etc.
Therefore, phd thesis autobiography, the lab was divided into two groups: the enzymologists under the guidance of Peter Bernfeld and carbohydrate chemists under Roger Jeanloz. I phd thesis autobiography to work on the purification of hog pancreas amylase.
Within a couple of years, we succeeded in crystallizing alpha-amylase from pork pancreas and soon after that, from a variety of other sources including human pancreas and saliva, two strains of A.
oryzaeB. subtilis and P. It is at that time that Eric A, phd thesis autobiography. Stein joined the laboratory, beginning a marvelous year collaboration and a lifelong phd thesis autobiography. It had always been my intention to go to the United States to pursue my studies in Biochemistry.
In those days, that field was in its infancy in most European universities to such an extent that I was asked to present the very first course in Enzymology as a Privat Docent at the University of Geneva in Two events hastened my departure for the USA: the untimely death of Kurt Meyer following an asthma attack and my being abruptly issued a US immigration visa, phd thesis autobiography.
Apparently, the US consulates abroad were clearing their files before the complicated McCarran Act would phd thesis autobiography into effect. Some friends who knew of my arrival in New York had arranged for me to give some seminars on my way to Pasadena: Maria Fuld at Pittsburgh and Henry Lardy at Phd thesis autobiography. To my utter surprise, I was offered a job in both places.
Then, upon my arrival at CalTech I found phd thesis autobiography letter from Hans Neurath, Chairman of the Department of Biochemistry at the University of Washington, inviting me to come to Seattle, apparently for the same purpose. I thought that the Americans had to be crazy since at that time, academic positions in Europe were one-in-a-million. I visited Seattle with my wife and thought that the surrounding mountains, forests and lakes were beautiful, reminiscent of Switzerland.
The Medical School was brand-new and when I was offered an Assistant Professorship, I accepted and have never regretted that decision. There were only seven of us on the faculty and we quickly became close friends. I remember the amused expressions of my colleagues seated in the back row of the class listening to my fractured English when lecturing the medical students, phd thesis autobiography.
Within six months of my arrival, Ed Krebs and I started to work together on glycogen phosphorylase. They believed that AMP had to serve some kind of co-factor function for that enzyme. In Geneva, on the other hand, we had purified potato phosphorylase for which there phd thesis autobiography no AMP requirement.
Even though essentially no information existed at that time on the evolutionary relationship of phd thesis autobiography, we knew that enzymes, whatever their origin, used the same co-enzymes to catalyze identical reactions. It seemed unlikely, therefore, that muscle phosphorylase would require AMP as a co-factor but not potato phosphorylase. We decided to try to phd thesis autobiography the role of this nucleotide in the phosphorylase reaction, phd thesis autobiography.
Of course, we never found out what AMP was doing: that problem was solved years later when Jacques Monod proposed his allosteric model for the regulation of enzymes. But what we stumbled on was phd thesis autobiography quite unexpected reaction: i. that muscle phosphorylase was regulated by phosphorylation-dephosphorylation.
This is yet another example of what makes fundamental research so attractive: one knows where one takes off but one never knows where one will end up. These were very exciting years when just about every experiment revealed something new and unexpected.
At first we worked alone in a small, phd thesis autobiography laboratory with stone sinks. Experiments were planned the night before and carried out the next day, phd thesis autobiography. We worked so closely together that whenever one of us had to leave the laboratory in the middle of an experiment, the other would carry on without a word of explanation.
Ed Krebs had a small group that continued his original work, determining the structure and function of DPNH-X, a derivative of NADH. I was still studying the alpha-amylases with Eric Stein. In collaboration with Bert Vallee, phd thesis autobiography, we were able to demonstrate that these enzymes were in reality calcium-containing metalloproteins. In those days, we waited all year for the next Federation Meeting or Gordon Conference. It was an occasion for me to get together with my friends on the East Coast: Herb and Eva Sober and Chris and Flossie Anfinsen from NIH, Bill and Inge Harrington from Johns Hopkins, phd thesis autobiography, Bert and Kuggie Vallee from the Brigham and Al and Lee Meister, then at Tufts and later at Cornell, and many others.
I have forgotten much about the meetings themselves. There was the excitement of hearing about the latest breakthroughs, the frantic preparations for talks that had to be given, and the numerous notebooks filled with information, questions and problems that had to be solved. I will never forget, though, the marvelous time we had together speaking far into the night about anything and everything.
Some of these friends are gone today but their memory is still vivid. I have two sons, phd thesis autobiography, François and Henri, from my first wife Nelly Gagnaux, a Swiss National who died in I married my present wife Beverley née Bullock from Eureka, California, phd thesis autobiography, in She has a daughter Paula from a first marriage.
All three of our children are now married and my two sons each has a son, phd thesis autobiography. I received the Werner Medal from the Swiss Chemical Society, the Lederle Medical Faculty Award; the Prix Jaubert from the University of Geneva and, jointly with Ed Krebs, the Senior Passano Award and the Steven C.
Beering Award from Indiana University. I received Doctorates Honoris Causa from the University of Montpellier, France and the University phd thesis autobiography Basel, phd thesis autobiography, Switzerland and was elected to the American Academy of Arts and Sciences in and to the National Academy of Sciences in The information is sometimes updated with an addendum submitted by the Laureate.
Medicine The Nobel Prize in Physiology or Medicine Edmond H. Fischer - Explore Biographical Physics Prizes Chemistry Prizes Medicine Prizes Literature Prizes Peace Prizes Prizes in Economic Sciences Facts Biographical Nobel Lecture Banquet speech Interview Photo gallery Other resources. Edmond H. Fischer died on 27 August Back to top Back To Top Takes users back to the top of the page, phd thesis autobiography. COMING UP Don't miss the Nobel Prize announcements October! Watch the live stream of the announcements.
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Edmond H. Fischer Biographical M emories of my early childhood are clouded with uncertainties because I was essentially separated from my parents since the early age of seven. I was born in Shanghai, China on April 6, My father had come there from Vienna, Austria after earning doctorates in law and business Oct 25, · Example Of Creative Autobiography Essay, Cheap Movie Review Ghostwriter Website Ca, Sample Dbq Essay Ap Us History, Bp Amoco Case Study 1 day ago · Japanese myself essay quotes for all types of essays autobiography paper of research in Example, everyday is a new day essay essay on why i want to be a counselor. Essay on a ideal person essay on our country india in words, exemple de conclusion de dissertation philosophique sur la
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